As a general medical journal, JAMA interacts with and serves numerous constituencies in medicine and health care, including authors, who provide content for the journal; peer reviewers, who assist in evaluation of the quality and validity of content; and readers, who use published content to expand knowledge and improve patient care. With the advent of the third year of the SARS-CoV-2 pandemic, we recognize and acknowledge many of the challenges that have affected and continue to affect these and other groups, including academic and practicing physicians, resident physicians and medical students, other health care professionals, as well as administrators, researchers, and public health officials. We express our deepest appreciation to and respect for the members of all these important groups and to many others in medicine and health care for their ongoing efforts in providing care for patients affected and not affected by COVID-19. We also express our appreciation to JAMA authors and reviewers for their contributions and support of the journal.