Muristek
Association of Maternal Antidepressant Prescription During Pregnancy and Danish School-aged Children’s Standardized Test Scores—Reply
In Reply We agree with Dr Braillon’s comment about our study that although the overall magnitude of the adjusted difference in mathematics test scores between children with and without maternal prescription fills for antidepressants in pregnancy was small (adjusted mean difference of −2.2), the finding may not necessarily be trivial because the magnitude of the difference increased in higher grades and with higher exposure levels. Braillon also asks whether it is possible to consider standardized tests in English, physics/chemistry, biology, and geography as additional outcomes. Unfortunately, these data were not available, so we are unable to provide the requested analyses. Regarding the request to restrict analyses to the 2007-2009 period, eFigure 2 in the Supplement of our article presented the mean test score differences between children with and without maternal prescription fills for antidepressants during pregnancy by each birth year. Although the prevalence of antidepressant prescription fills in pregnancy was higher in the most recent birth years, there was no clear time trend in the association with the test scores (adjusted mean difference in mathematics was −2.4 for children born in 2007, −1.7 for those born in 2008, and −2.0 for those born in 2009).
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